What the science says about condoms

Science library Health and safety

Last reviewed: Written and reviewed by the Loviux Team. 16 studies

We check every summary against the study's original abstract: the quotation is verbatim and the figures match. How we verify our information

This page reports on published research. It is not medical advice and does not replace a healthcare professional.

If you have pain or discomfort, speak to a healthcare professional.

On this page
  1. In 30 seconds
  2. What the studies say overall
  3. Where they disagree
  4. Limits of the evidence
  5. The studies, one by one
  6. What this means in practice
  7. Other topics in the library

In 30 seconds

What the studies say
The condom is among the most studied tools in sexual health. A Cochrane review of heterosexual couples in which one partner had HIV estimated that always using one reduces new infections by around eighty percent (Weller et al., 2001).
The main limitation
The large figure for protection against HIV comes from older studies of heterosexual couples (Weller et al., 2001).
In practice
Using one every time was what was associated with the large reduction in HIV (Weller et al., 2001).

What kind of studies there are

  • Syntheses of studies 3
  • Randomised trials 4
  • Observational 5
  • Descriptive or expert opinion 4

We classify each study by its design. A synthesis of many studies or a randomised trial supports firmer conclusions than a survey or an expert opinion. The design does not tell you whether a result is good or bad.

What the studies say overall

The condom is among the most studied tools in sexual health. A Cochrane review of heterosexual couples in which one partner had HIV estimated that always using one reduces new infections by around eighty percent (Weller et al., 2001).

And using the female condom together with the male condom prevented more sexually transmitted infections than using the male condom alone, according to a review of fifteen studies (Wiyeh et al., 2020).

Non-latex condoms, such as polyurethane ones, are the alternative for people with a latex allergy. A meta-analysis found that they break more often than latex ones, although they remain an acceptable option (Gallo et al., 2006).

The trials do not fully agree: in one, breakage of the polyurethane condom was no different from latex, in another it had more failures although all were low, and in a third it was not shown to protect equally well against pregnancy (Potter et al., 2003; Potter et al., 2024; Steiner et al., 2003).

Many failures have to do with how the condom is used. In a trial of almost five thousand acts of intercourse, using lubricant reduced breakage and slippage, in both anal and vaginal sex (Siegler et al., 2019).

Among university students in the United States, fit problems and other user errors were associated with breakage, and in Flanders discomfort and fit appear as barriers to using one (Butler et al., 2025; Dewaele et al., 2024).

In two studies of men who have sex with men, failures were common, and more so under the influence of substances (Sandfort et al., 2025; Gray et al., 2024). Talking about condoms with a partner was associated with using them consistently (Edison et al., 2022).

The type of lubricant matters: in a laboratory study from 1989, one minute of contact with mineral oil reduced the strength of latex by around ninety percent (Voeller et al., 1989).

The female condom, for its part, takes practice: among women in Durban, failures dropped sharply between the first and fourth period of use, and half of a group of Australian women had some difficulty inserting it (Beksinska et al., 2015; Fenwick et al., 2021). The newer designs did not fail more than the reference model (Beksinska et al., 2013).

Where they disagree

On the material, the trials do not give a single result: polyurethane fails somewhat more than latex in some studies and the same in others, and for preventing pregnancy one did not show the same effectiveness (Gallo et al., 2006; Potter et al., 2003; Potter et al., 2024; Steiner et al., 2003).

Breakage figures also vary a great deal depending on the population and the situation: a stable couple in a trial is not the same as intercourse under the influence of substances (Sandfort et al., 2025; Gray et al., 2024).

Limits of the evidence

The large figure for protection against HIV comes from older studies of heterosexual couples (Weller et al., 2001). Several studies are surveys that depend on what people remember, and the mineral oil one is a laboratory test, without people (Butler et al., 2025; Dewaele et al., 2024; Voeller et al., 1989).

None compares specific brands.

The studies, one by one

We have gathered 16 verified studies. Each summary is our own; the quotation in inverted commas is taken word for word from the original abstract, in English.

Type of study: Systematic review2001

Condom effectiveness in reducing heterosexual HIV transmission.

What they found: A systematic review of 14 studies in heterosexual couples where one partner had HIV and the other did not found that consistent condom use is associated with a reduction of approximately 80 % in HIV incidence. (Weller et al., 2001)

Population Heterosexual couples with one partner who has HIV Journal Cochrane Database Syst Rev

Verbatim quotation from the original abstract (in English)

“This review indicates that consistent use of condoms results in 80% reduction in HIV incidence.” Weller et al., 2001

See the original: DOI · PubMed

Type of study: Meta-analysis2006

Non-latex versus latex male condoms for contraception.

What they found: A meta-analysis found more clinical breakage with non-latex condoms than with latex ones (odds ratio of 2.6 to 5.0), although they remain an acceptable alternative for people with an allergy. (Gallo et al., 2006)

Population Male condom users in randomized trials Journal Cochrane Database Syst Rev

Verbatim quotation from the original abstract (in English)

“The nonlatex condoms had significantly higher rates of clinical breakage than their latex comparison condoms” Gallo et al., 2006

See the original: DOI · PubMed

Type of study: Meta-analysisSample n = 6,9212020

Effectiveness of the female condom in preventing HIV and sexually transmitted infections: a systematic review and meta-analysis.

What they found: A review of fifteen studies with 6921 women concludes that using the female condom together with the male condom prevents more sexually transmitted infections than using the male condom alone. (Wiyeh et al., 2020)

Population Women in female condom trials Journal BMC Public Health

Verbatim quotation from the original abstract (in English)

“The use of female plus male condoms is more effective than use of male condoms only in preventing STIs and may be as effective as the male condom only in preventing HIV.” Wiyeh et al., 2020

See the original: DOI · PubMed

Type of study: Randomised controlled trialSample n = 9012003

Contraceptive effectiveness of a polyurethane condom and a latex condom: a randomized controlled trial.

What they found: In 901 couples, the polyurethane condom was not shown to be as effective as the latex one in preventing pregnancy (9.0 % versus 5.4 % at six months). (Steiner et al., 2003)

Population Couples using the condom as their only contraceptive Journal Obstet Gynecol

Verbatim quotation from the original abstract (in English)

“The polyurethane condom was not shown to be as effective as the latex comparator condom for pregnancy prevention.” Steiner et al., 2003

See the original: DOI · PubMed

Type of study: Randomised controlled trial2003

Clinical breakage, slippage and acceptability of a new commercial polyurethane condom: a randomized, controlled study.

What they found: In a trial of a polyurethane condom, clinical breakage was 0.6 % versus 1.3 % for the latex one, with no significant difference. (Potter et al., 2003)

Population Condom users in the Paris region Journal Contraception

Verbatim quotation from the original abstract (in English)

“The polyurethane condom was therefore equivalent to the latex condom in terms of clinical failure rate.” Potter et al., 2003

See the original: DOI · PubMed

Type of study: Randomised controlled trialSample n = 3002024

Clinical breakage, slippage and acceptability of two commercial ultra-thin polyurethane male condoms compared to a commercial thin latex condom: a randomised, masked, 3 way crossover, multi centre controlled study (SAGCS 2).

What they found: In 300 couples, ultra-thin polyurethane condoms had more failures (breakage and slippage) than the control latex condom, but all had low failure rates. (Potter et al., 2024)

Population Sexually active heterosexual couples aged 18 to 45 Journal Reprod Health

Verbatim quotation from the original abstract (in English)

“Although the total failure rates (breakage and slippage) for the polyurethane condoms were higher than for the control Latex C condom, all condoms performed extremely well with low failure rates compared to similar condom studies.” Potter et al., 2024

See the original: DOI · PubMed

Type of study: Randomised controlled trialSample n = 6002013

Performance and safety of the second-generation female condom (FC2) versus the Woman's, the VA worn-of-women, and the Cupid female condoms: a randomised controlled non-inferiority crossover trial.

What they found: In a trial of 600 women, three new female condom designs were not inferior to the FC2 in failures, within the expected margin. (Beksinska et al., 2013)

Population Women aged 18 to 45 in Shanghai and Durban Journal Lancet Glob Health

Verbatim quotation from the original abstract (in English)

“Non-inferiority was shown for all condom failure events for the three new devices versus the FC2, within the predefined margin.” Beksinska et al., 2013

See the original: DOI · PubMed

Type of study: Analysis of placebo groups from clinical trials2019

Levels of clinical condom failure for anal sex: A randomized cross-over trial.

What they found: In a randomized trial of 4884 acts of intercourse with a condom, failure (breakage or slippage) was lower when lubricant was used, in both anal and vaginal sex. (Siegler et al., 2019)

Population Men who have sex with men and men who have sex with women, in Atlanta Journal EClinicalMedicine

Verbatim quotation from the original abstract (in English)

“Sex acts for which lubricant was used had lower failure for both anal and vaginal sex, with no difference in odds of failure between them.” Siegler et al., 2019

See the original: DOI · PubMed

Type of study: Analysis of placebo groups from clinical trialsSample n = 3002015

The female condom learning curve: patterns of female condom failure over 20 uses.

What they found: A randomized crossover trial of women in Durban found that female condom failures dropped from 7.7 % in the first period of use to 1.2 % in the fourth, regardless of the model. (Beksinska et al., 2015)

Population Women in Durban (South Africa) who use the female condom Journal Contraception

Verbatim quotation from the original abstract (in English)

“the number of failures in the first condom use period was 103 (7.7%), decreasing to 43 events (3.2%) in the second, 33 (2.5%) in the third and 16 (1.2%) in the fourth.” Beksinska et al., 2015

See the original: DOI · PubMed

Type of study: Observational studySample n = 4012025

Correlates of Condom Failure in Men Who Have Sex With Men in Kenya, Malawi, and South Africa: Findings From the HIV Prevention Trials Network 075 Study.

What they found: A cohort study of men who have sex with men in Kenya, Malawi and South Africa found that condom slippage occurred in 10.2 % of acts of intercourse and breakage in 11.7 %, and that both were more frequent under the influence of substances. (Sandfort et al., 2025)

Population Men who have sex with men in Kenya, Malawi and South Africa Journal Sex Transm Dis

Verbatim quotation from the original abstract (in English)

“Condom slippage was reported in 194 (10.2%) of the 1908 sexual interactions reported by participants and breakage in 223 (11.7%) interactions.” Sandfort et al., 2025

See the original: DOI · PubMed

Type of study: Observational studySample n = 3432024

Condom Failure Among HIV-Negative Men in Serodiscordant Relationships in Australia, Brazil, and Thailand.

What they found: In 343 male serodiscordant couples, there were 717 condom failures (breakage or slippage) in about 25,831 acts with a condom, and 26.5 % of HIV-negative participants reported some failure with their study partner. (Gray et al., 2024)

Population HIV-negative men in serodiscordant couples in Australia, Brazil and Thailand Journal AIDS Behav

Verbatim quotation from the original abstract (in English)

“was reported by 91/343 (26.5%) HIV-negative partners” Gray et al., 2024

See the original: DOI · PubMed

Type of study: Survey (cross-sectional study)Sample n = 1,5842025

Condom Acquisition, Errors, and Breakage among U.S. Cisgender College Students.

What they found: A survey of 1584 US university students who had used an external condom in the past year found that fit problems, slippage and other user errors were associated with condom breakage. (Butler et al., 2025)

Population Cisgender US university students who used an external condom in the past year Journal Arch Sex Behav

Verbatim quotation from the original abstract (in English)

“Multivariate logistic regression indicated that relationship status, applying condom on wrong side, adding condom after sex started, removing condom during sex, condom slipping off, and problems with fit were predictors for condom breakage.” Butler et al., 2025

See the original: DOI · PubMed

Type of study: Analysis of placebo groups from clinical trialsSample n = 2,2912022

Sexual Communication and Sexual Consent Self-Efficacy Among College Students: Implications for Sexually Transmitted Infection Prevention.

What they found: An analysis of a cluster-randomized trial with 2291 university students found that those who communicated about condom use and had high self-efficacy for obtaining consent were the most likely to use them consistently. (Edison et al., 2022)

Population US university students Journal J Adolesc Health

Verbatim quotation from the original abstract (in English)

“Odds of consistent condom use were highest among students reporting condom use communication and high self-efficacy to obtain sexual consent (AOR = 1.99, 95% CI = 1.58, 2.51).” Edison et al., 2022

See the original: DOI · PubMed

Type of study: Survey (cross-sectional study)2024

Contextualized Experiences and Predictors of Condom Use in a Flemish Population: A Mixed Methods Study.

What they found: A mixed-methods study in Flanders, with a survey of more than 14,000 participants, concludes that practical barriers, such as discomfort and fit, influence condom use. (Dewaele et al., 2024)

Population General population of Flanders (Belgium) Journal Int J Environ Res Public Health

Verbatim quotation from the original abstract (in English)

“These findings underscore the complexity of CU behavior, showing that practical barriers (e.g., discomfort, fit) and personal beliefs play pivotal roles.” Dewaele et al., 2024

See the original: DOI · PubMed

Type of study: Survey (cross-sectional study)Sample n = 2842021

Views and experiences of the female condom in Australia: An exploratory cross-sectional survey of cisgender women.

What they found: Among 284 Australian women who tried the female condom, 51 % reported some difficulty inserting it. (Fenwick et al., 2021)

Population Cisgender heterosexual women in New South Wales Journal PLoS One

Verbatim quotation from the original abstract (in English)

“Fifty-one percent (104/205) reported experiencing some difficulty in insertion” Fenwick et al., 2021

See the original: DOI · PubMed

Type of study: Laboratory study1989

Mineral oil lubricants cause rapid deterioration of latex condoms.

What they found: In a laboratory test, sixty seconds of contact with mineral oil reduced the strength of latex condoms by around 90 %. (Voeller et al., 1989)

Population Commercial latex condoms (laboratory trial) Journal Contraception

Verbatim quotation from the original abstract (in English)

“As little as sixty seconds' exposure of commercial latex condoms to mineral oil, a common component of hand lotions and other lubricants used during sexual intercourse, caused approximately 90% decrease in the strength of the condoms” Voeller et al., 1989

See the original: DOI · PubMed

What this means in practice

  • Using one every time was what was associated with the large reduction in HIV (Weller et al., 2001).
  • With a latex condom, no oils: in the laboratory, mineral oil weakened it within a minute (Voeller et al., 1989). Adding a suitable lubricant reduced breakage and slippage in one trial (Siegler et al., 2019).
  • Fit matters: fit problems were associated with breakage (Butler et al., 2025).
  • With a latex allergy, polyurethane is an acceptable alternative, although it may break somewhat more (Gallo et al., 2006).
  • The female condom takes practice: failures drop with use (Beksinska et al., 2015).
  • If it breaks or comes off, speak to a healthcare professional as soon as possible.

If you have pain or discomfort, speak to a healthcare professional.

Other topics in the library

All topics in the science library